Matthew G. Deneke, M.D. Gastroenterologist
Primary Appointment Location
Gastroenterology Clinic
4110 Outpatient Circle
Outpatient Center
Third Floor, Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Overview
- Areas of Expertise
- Organ Transplantation
- Digestive Health
- Accepting New Patients
- Yes
- Patient Type
- Adults
- Language
- English
About Dr. Deneke
Clinical Biography
Dr. Deneke initially joined the faculty at UAMS in 2005 as an Assistant Professor of Medicine for the Division of General Internal Medicine. While faculty, he served as Medical Director of the ambulatory teaching clinic for internal medicine residents and as the Associate Practice Director for UAMS Internal Medicine Clinics. After five years, Dr. Deneke stepped down as faculty to pursue additional training in gastroenterology and hepatology. He rejoined the UAMS faculty in the Division of Gastroenterology and Hepatology in 2014. He is currently the program director for the UAMS Gastroenterology Fellowship Program. He is a part of the UAMS Liver Transplant team and also operates the UAMS Fatty Liver Disease Clinic.
His clinical interests include liver disease, with a focus on nonalcoholic fatty liver disease, complications of liver disease, and liver transplantation.
Dr. Deneke's Academic Background
Faculty Appointments
- Department of Internal Medicine — Division of Gastroenterology and Hepatology
- Assistant Professor
Education and Training
- Medical School
- University of Arkansas for Medical Sciences
- Residency
- University of Alabama at Birmingham
- Fellowship
- University of Arkansas for Medical Sciences
- Fellowship
- Mayo Clinic
Transplant Hepatology
Professional Certifications
- American Board of Internal Medicine — Internal Medicine
Dr. Deneke's Research
UAMS Research Profile
Each UAMS faculty member has a research profile page that includes biographical and contact information, a list of their most recent grant activity and a list of their PubMed publications.
Conditions Diagnosed or Treated by Dr. Deneke
UAMS Health providers care for a broad range of conditions, some of which may not be listed below.
Medical Treatments and Procedures Performed or Prescribed by Dr. Deneke
UAMS Health providers perform and prescribe a broad range of treatments and procedures, some of which may not be listed below.
Dr. Deneke's Areas of Expertise
Organ Transplantation
Organ transplants are often life-saving treatments for conditions where an organ has failed or is no longer functioning properly.
Digestive Health
With highly skilled and trained specialists and the latest technology, UAMS Health's digestive health services are the most complete in the state.
Locations Where Dr. Deneke Practices
Gastroenterology Clinic , Primary Location
4110 Outpatient Circle
Outpatient Center
Third Floor, Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Liver Transplant Clinic at the UAMS Medical Center
4110 Outpatient Circle
Outpatient Center
Third Floor, Suite 3150
Little Rock, AR 72205
- Appointment Phone Number
- 800-552-8026
New and Returning Patients
Paracentesis and Thoracentesis Clinic
4110 Outpatient Circle
Outpatient Center
Third Floor, Suite 3/150
Little Rock, AR 72205
- Appointment Phone Number
- 501-686-6411
New and Returning Patients
Comment
The doctor listened to my concerns and explained everything as if talking to a friend. Gave recommendations and personally informed me of the results of the testing that was ordered shortly after the results were in. I would recommend his service and expertise to anyone needing a specialist of his nature.
Date
Jul 17, 2026Comment
Dr Deneke truly is an excellent physician. He is concerned, talks at your level of understanding, and answers all questions you may have.
Date
Jul 09, 2026Comment
Good experience from reception to tech to nurse to doctor!
Date
Jun 14, 2026Comment
Very impressed with doctor Deneke. He answered all questions and established a solid plan. [......] We were very pleased with the care given.
Date
Jun 07, 2026Comment
Dr. Matthew Deneke and his team are the best. They helped me through the most trying time of my life. Saved my life with my liver transplant and many months of treatment. Couldn't recommend a better care provider. Dr. Deneke is the man!
Date
Jun 06, 2026Comment
Matthew Deneke is a patient, empathetic, extremely well respected physician who has basically guided me through a life threatening situation. He is as trusted doctor as I have ever had
Date
May 23, 2026Comment
Dr Deneke is an outstanding doctor, an asset to UAMS
Date
Apr 03, 2026Comment
Truly enjoy both of current Doctors and assistants
Date
Feb 27, 2026Comment
This was just a 6 month checkup ( that took 7 additional months) and I am doing very well -no problems at all but felt rushed
Date
Feb 13, 2026Comment
It was good
Date
Feb 11, 2026